Allopregnanediol, or 5α-pregnane-3α,20α-diol, is an endogenous metabolite of progesterone and allopregnanolone and an isomer of pregnanediol (5β-pregnan-3α,20α-diol). It has been found to act like a partial agonist of an allosteric site of the GABA receptor and hence might play a biological role as a neurosteroid. It has also been found to act as an agonist of the human pregnane X receptor, albeit with an EC50 that is more than an order of magnitude lower than that of other endogenous pregnanes like pregnenolone, pregnanediol, allopregnanedione, and allopregnanolone.
"}{"type":"standard","title":"James Lane Allen","displaytitle":"James Lane Allen","namespace":{"id":0,"text":""},"wikibase_item":"Q3297881","titles":{"canonical":"James_Lane_Allen","normalized":"James Lane Allen","display":"James Lane Allen"},"pageid":1255209,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/8/8c/Photo_of_James_Lane_Allen.jpg/330px-Photo_of_James_Lane_Allen.jpg","width":320,"height":397},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/8/8c/Photo_of_James_Lane_Allen.jpg","width":1029,"height":1277},"lang":"en","dir":"ltr","revision":"1264390242","tid":"359e1a91-bfdd-11ef-8872-047a333d9b7c","timestamp":"2024-12-21T20:50:28Z","description":"American novelist (1849–1925)","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/James_Lane_Allen","revisions":"https://en.wikipedia.org/wiki/James_Lane_Allen?action=history","edit":"https://en.wikipedia.org/wiki/James_Lane_Allen?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:James_Lane_Allen"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/James_Lane_Allen","revisions":"https://en.m.wikipedia.org/wiki/Special:History/James_Lane_Allen","edit":"https://en.m.wikipedia.org/wiki/James_Lane_Allen?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:James_Lane_Allen"}},"extract":"James Lane Allen was an American novelist and short story writer whose work, including the novel A Kentucky Cardinal, often depicted the culture and dialects of his native Kentucky. His work is characteristic of the late 19th-century local color era, when writers sought to capture the vernacular in their fiction. Allen has been described as \"Kentucky's first important novelist\".","extract_html":"
James Lane Allen was an American novelist and short story writer whose work, including the novel A Kentucky Cardinal, often depicted the culture and dialects of his native Kentucky. His work is characteristic of the late 19th-century local color era, when writers sought to capture the vernacular in their fiction. Allen has been described as \"Kentucky's first important novelist\".
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{"fact":"A cat's smell is their strongest sense, and they rely on this leading sense to identify people and objects; a feline's sense of smell is 14x better than a human's.","length":163}
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